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May 29, 2024Effectiveness of Saxenda for Weight Loss
Saxenda injections; Patients have experienced significant weight loss while using Saxenda. The average weight loss in trials was 6.4% of total starting weight over 68 weeks, compared to less than 2% with a placebo. Participants also received counseling on diet and exercise strategies.
DRUG COMPARISONS
| BRAND NAME | ACTIVE INGREDIENT | TYPICAL WEIGHT LOSS | APPROVED USE |
| Saxenda | Liraglutide 3 mg | 6.4%1 | Weight Management |
| Wegovy | Semaglutide 2.4 mg | 15.8%1 | |
| Victoza | Liraglutide 1.8 mg | 4.7%2 | Type 2 Diabetes Management |
| Ozempic | Semaglutide 2 mg | 6.3%3 | |
| As a percentage of original body weight over a 68-week trial.As a percentage of original body weight over a 56-week trial.As a percentage of original body weight over a 40-week trial. | |||
Saxenda effectively manages weight by suppressing appetite, slowing gastric emptying and promoting insulin production.
Saxenda, Wegovy and Zepbound (tirzepatide) are the only GLP-1 medications FDA-approved for weight loss. Other GLP-1s approved for Type 2 diabetes may produce weight loss, but they do not have FDA approval for that use. Using a medication off-label can pose serious health risks.
Saxenda injections
Dosage Information
Saxenda is taken in a gradually increasing dose to allow the body to adjust. The standard dose is 3.0 mg per day.
The treatment begins with a daily injection of 0.6 mg and gradually increases until the maintenance dose of 3 mg daily is reached. You should return to your doctor for a check-up after four months of use.
Saxenda Dosing
- Week 1: 0.6 mg/day
- Week 2: 1.2 mg/day
- Week 3: 1.8 mg/day
- Week 4: 2.4 mg/day
- Week 5 and beyond: 3.0 mg/day
Source: FDA
How Much Does Saxenda Cost?
According to Novo Nordisk, Saxenda has a list price of $1,349 without insurance. However, the out-of-pocket price may be substantially lower if your health insurance covers it.
Consult your health care professional, pharmacy or insurance provider for updated and accurate pricing information.
Novo Nordisk previously offered a savings program for Saxenda, but it expired in 2023. Other savings programs may be available.
Saxenda Boxed Warning
Saxenda has an FDA boxed warning — the Agency’s most serious warning — due to an increased risk of thyroid tumors from liraglutide. Rats and mice have developed thyroid C-cell tumors while taking liraglutide in lab tests, but it’s unclear if humans are at risk.
Who Should Not Take Saxenda?
You should not take Saxenda if you have a personal or family history of certain types of thyroid cancers. If you have the rare genetic disorder multiple endocrine neoplasia (MEN), you should not take Saxenda. If you are pregnant or have a known allergic reaction or hypersensitivity to ingredients in Saxenda, you shouldn’t take it.
